Pathway-based Polygenic Risk for Severe Depression Implicates Drug Metabolism in a Large Han Chinese Cohort

Using low-coverage whole genome sequencing in the CONVERGE cohort (N = 10,640), we derived polygenic risk scores specific to each of over 300 molecular pathways previously shown to be relevant to severe psychopathology. We then identified gene pathways significantly predictive of recurrent depression over and above global genomic risk.